Enhanced nuclear factor-kappa B-associated Wnt-1 expression in hepatitis B- and C-related hepatocarcinogenesis: identification by functional proteomics.

@article{Lee2006EnhancedNF,
  title={Enhanced nuclear factor-kappa B-associated Wnt-1 expression in hepatitis B- and C-related hepatocarcinogenesis: identification by functional proteomics.},
  author={Richard T. Lee and D W Tai and Cha-Ju Cheng and Chi-Shu Sun and Ching-Yih Lin and Ming-Jen Sheu and W. P. Andrew Lee and Cheng-Yuan Peng and Andrew H-J Wang and S F Tsai},
  journal={Journal of biomedical science},
  year={2006},
  volume={13 1},
  pages={
          27-39
        }
}
Chronic infections with hepatitis B and C viruses (HBV and HCV) are etiologically linked to hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Both viruses may induce activation of nuclear factor-kappa B (NF-kappaB) in hepatocytes that plays a crucial role in the regulation of cell growth and apoptosis. Functional proteomics analysis of proteins associated with NF-kappaB signaling complexes in both viruses-related HCC tumor and non-tumor tissues may disclose possible common… CONTINUE READING

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