Enhanced norepinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus.

@article{FlorinLechner1996EnhancedNR,
  title={Enhanced norepinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus.},
  author={S M Florin-Lechner and J P Druhan and Gary Aston-Jones and Rita J Valentino},
  journal={Brain research},
  year={1996},
  volume={742 1-2},
  pages={89-97}
}
The present study was designed to determine the relationship between the discharge of noradrenergic locus coeruleus (LC) neurons and norepinephrine release in the medial prefrontal cortex, a target of LC projections. The LC was electrically stimulated at varying frequencies and patterns for 20 min and extracellular norepinephrine levels were measured in the medial prefrontal cortex of halothane-anesthetized rats using in vivo microdialysis. Electrical stimulation of the LC at 3-10 Hz with an… CONTINUE READING
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