Enhanced nitric oxide production during lead (Pb2+) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons

@article{Neal2012EnhancedNO,
  title={Enhanced nitric oxide production during lead (Pb2+) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons},
  author={A. P. Neal and K. Stansfield and T. Guilarte},
  journal={Brain Research},
  year={2012},
  volume={1439},
  pages={88-95}
}
  • A. P. Neal, K. Stansfield, T. Guilarte
  • Published 2012
  • Biology, Medicine
  • Brain Research
  • We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neurotrophic factor (BDNF) and exogenous addition of BDNF can recover the effects of Pb(2+) on both presynaptic protein expression and presynaptic vesicular release. NMDAR activity can… CONTINUE READING
    17 Citations
    Lead exposure inhibits expression of SV2C through NRSF.
    • 1
    Nitric oxide modulates lead content during lead-induced cell killing in yeast cells
    • PDF

    References

    SHOWING 1-10 OF 48 REFERENCES
    Molecular Neurobiology of Lead (Pb2+): Effects on Synaptic Function
    • 123
    NMDAR-2A subunit protein expression is reduced in the hippocampus of rats exposed to Pb2+ during development.
    • 68
    Lead neurotoxicity: From exposure to molecular effects
    • 307