Enhanced nitric oxide and cyclic GMP formation plays a role in the anti-platelet activity of simvastatin.

@article{Chou2008EnhancedNO,
  title={Enhanced nitric oxide and cyclic GMP formation plays a role in the anti-platelet activity of simvastatin.},
  author={T C Chou and Y Lin and W-C Wu and K. W. Chu},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 6},
  pages={1281-7}
}
BACKGROUND AND PURPOSE It has been found that 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) exert various vascular protective effects, beyond their cholesterol-lowering property, including inhibition of platelet-dependent thrombus formation. The objective of the present study was to determine whether the nitric oxide (NO)/cyclic GMP-mediated processes in platelets contribute to the anti-aggregatory activity of simvastatin. EXPERIMENTAL APPROACH After rabbit… CONTINUE READING

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