Enhanced neurotransmitter release is associated with reduction of neuronal branching in a Drosophila mutant overexpressing frequenin.

@article{AngautPetit1998EnhancedNR,
  title={Enhanced neurotransmitter release is associated with reduction of neuronal branching in a Drosophila mutant overexpressing frequenin.},
  author={Denise Angaut-Petit and Peter T{\'o}th and O Rogero and Lucette Faille and Francisco J Tejedor and Alberto Ferr{\'u}s},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 2},
  pages={423-34}
}
Frequenin is a Drosophila Ca2+ binding protein whose overexpression causes a chronic facilitation of transmitter release at the larval neuromuscular junction and multiple firing of action potentials. These functional abnormalities are similar to those found in other hyperexcitable mutants (Shaker, ether-a-gogo, Hyperkinetic) which, in turn, exhibit increased branching at the motor nerve endings. We report here that mutants which overexpress frequenin have motor nerve terminals with reduced… CONTINUE READING

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