Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR).

@article{Sinha2009EnhancedNL,
  title={Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR).},
  author={Rohit Sinha and Amrita Pathak and Ashok Kumar and Meenakshi Tiwari and Ashutosh Kumar Shrivastava and Madan Madhav Godbole},
  journal={Molecular and cellular neurosciences},
  year={2009},
  volume={40 3},
  pages={354-64}
}
Recognition of the molecular events that lead to enhanced cell death is vital to understand the developmental cerebellar defects under hypothyroidism. Though neurotrophins promote the survival and development of neurons in the cerebellum, but the mechanism of their insufficiency mediated cell loss under hypothyroidism is unknown. Here in developmental hypothyroid rat model we report that hypothyroidism induced neuronal loss involve down regulation of neurotrophic survival signaling and… CONTINUE READING

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