Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice.

@article{Le1997EnhancedND,
  title={Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice.},
  author={Dean A. Le and Sumantra Das and Yanming F. Wang and Takahiro Yoshizawa and Yasnory F. Sasaki and Miwa Takasu and Andr{\'a}s Nemes and Michael Mendelsohn and Pieter Dikkes and Stuart Lipton and Nobuki Nakanishi},
  journal={Brain research. Molecular brain research},
  year={1997},
  volume={52 2},
  pages={235-41}
}
Excitatory amino acid (EAA) receptors play an important role in neuronal cell death in acute cerebral ischemia. Blocking the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of EAA receptor has been shown to reduce cell death in global cerebral ischemia. However their role in focal stroke, although suggestive, has remained more contentious. To clarify this issue, we generated transgenic mice overexpressing the AMPA receptor (AMPAR) subunit GluR2-flip which would increase… CONTINUE READING