Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

@inproceedings{Zhu2016EnhancedNM,
  title={Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period},
  author={Yangzi Zhu and Yu Wang and Ruiqin Yao and Ting Hao and Junli Cao and He Huang and Liwei Wang and Yuqing Wu},
  booktitle={Journal of Neuroinflammation},
  year={2016}
}
Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases and premature mortality later in life. One mechanistic hypothesis for this phenomenon is that early life adversity alters the expression or functioning of the glucocorticoid receptor (GR) throughout the course of life and thereby increases sensitivity to inflammatory stimulation. An exaggerated pro-inflammatory response is generally considered to be a key cause of postoperative cognitive… CONTINUE READING
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