Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.

  title={Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.},
  author={Kunlin Jin and V. A. Galvan and Lin Xie and Xiao Ou Mao and Olivia F Gorostiza and Dale E. Bredesen and David Greenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 36},
Neurogenesis continues in the adult brain and is increased in certain pathological states. We reported recently that neurogenesis is enhanced in hippocampus of patients with Alzheimer's disease (AD). We now report that the effect of AD on neurogenesis can be reproduced in a transgenic mouse model. PDGF-APP(Sw,Ind) mice, which express the Swedish and Indiana amyloid precursor protein mutations, show increased incorporation of BrdUrd and expression of immature neuronal markers in two… CONTINUE READING
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