Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model.

@article{Yoshiyama2005EnhancedNT,
  title={Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model.},
  author={Y. Yoshiyama and K. Uryu and M. Higuchi and L. Longhi and R. Hoover and S. Fujimoto and T. Mcintosh and V. Lee and J. Trojanowski},
  journal={Journal of neurotrauma},
  year={2005},
  volume={22 10},
  pages={
          1134-41
        }
}
Traumatic brain injury (TBI) is a risk factors for Alzheimer's disease (AD), and repetitive TBI (rTBI) may culminate in dementia pugilistica (DP), a syndrome characterized by progressive dementia, parkinsonism, and the hallmark brain lesions of AD, including neurofibrillary tangles (NFTs), formed by abnormal tau filaments and senile plaques (SPs) composed of Abeta fibrils. Previous study showed that mild rTBI (mrTBI) accelerated the deposition of Abeta in the brains of transgenic (Tg) mice… Expand
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