Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure.

@article{Lipkin1997EnhancedNR,
  title={Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure.},
  author={Graham W Lipkin and Anne Beatrice Dawnay and Steven M. Harwood and W. R. Cattell and Anthony E. G. Raine},
  journal={Kidney international},
  year={1997},
  volume={52 3},
  pages={792-801}
}
Atrial natriuretic factor (ANF) has natriuretic, renin-suppressing and chronic hypotensive actions that may be utilized by inhibition of ANF degradation by neutral endopeptidase, E.C.24.11 (NEP). Three groups of 8 male patients [GFR 103 +/- 8 (Normal), 64 +/- 6 (Moderate CRF), and 16 +/- 2 ml/min (Severe CRF)] received 100 mg i.v. bolus of the NEP inhibitor candoxatrilat or placebo in random order in a double-blind crossover study. GFR (51CR-EDTA), ERPF (125I-hippuran). ANF (IRMA), urinary cGMP… CONTINUE READING

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