Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.

@article{Katsumata1997EnhancedML,
  title={Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.},
  author={Naoki Katsumata and Hiroaki Shimokawa and Masao Seto and Toshiyuki Kozai and T Yamawaki and Kouichi Kuwata and Kensuke Egashira and Ichiro Ikegaki and Tomoichiro Asano and Yuki Sasaki and Akira Takeshita},
  journal={Circulation},
  year={1997},
  volume={96 12},
  pages={4357-63}
}
BACKGROUND Although coronary artery spasm plays an important role in a wide variety of ischemic heart diseases, the intracellular mechanism for the spasm remains to be clarified. We examined the role of myosin light chain (MLC) phosphorylations, a key mechanism for contraction of vascular smooth muscle, in our swine model with interleukin-1beta (IL-1beta). METHODS AND RESULTS IL-1beta was applied chronically to the porcine coronary arteries from the adventitia to induce an inflammatory… CONTINUE READING

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