Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure.

@article{Chu2002EnhancedMC,
  title={Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure.},
  author={Guoxiang Chu and Andrew N. Carr and Karen Young and J. William Lester and Atsuko Yatani and Atsushi Sanbe and Melissa C. Colbert and Steven M. Schwartz and Konrad F. Frank and Paul D Lampe and Jeffrey Robbins and Jeffery D Molkentin and Evangelia G Kranias},
  journal={Cardiovascular research},
  year={2002},
  volume={54 1},
  pages={105-16}
}
OBJECTIVE Impaired myocyte Ca2+ handling is a common characteristic of failing hearts and increases in calcineurin activity, a Ca2+-sensitive phosphatase, have been implicated in heart failure phenotype. Transgenic mice with cardiac-specific expression of an active form of calcineurin display depressed function, hypertrophy and heart failure. We examined… CONTINUE READING