Enhanced mutational activity of Vkappa gene rearrangements in systemic lupus erythematosus.

@article{Doerner1999EnhancedMA,
  title={Enhanced mutational activity of Vkappa gene rearrangements in systemic lupus erythematosus.},
  author={Thomas Doerner and C Heimb{\"a}cher and Nancy L. Farner and Peter E Lipsky},
  journal={Clinical immunology},
  year={1999},
  volume={92 2},
  pages={188-96}
}
To determine the differential impact of somatic hypermutation and selective influences on the light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern of somatic hypermutations were compared between the productive and nonproductive Vkappa gene repertoire manifested by individual CD19(+) B cells in a patient with SLE. The mutational frequency of nonproductive rearrangements in the SLE patient was significantly (P < 0.001) increased (3.7 x 10(-2)) compared to… CONTINUE READING
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