Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.

@article{Dobson2002EnhancedMR,
  title={Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.},
  author={Allison W. Dobson and Valentina I. Grishko and Susan P Ledoux and Mark R Kelley and Glenn L. Wilson and Mark N. Gillespie},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 1},
  pages={L205-10}
}
In rat cultured pulmonary arterial (PA), microvascular, and venous endothelial cells (ECs), the rate of mitochondrial (mt) DNA repair is predictive of the severity of xanthine oxidase (XO)-induced mtDNA damage and the sensitivity to XO-mediated cell death. To examine the importance of mtDNA damage and repair more directly, we determined the impact of mitochondrial overexpression of the DNA repair enzyme, Ogg1, on XO-induced mtDNA damage and cell death in PAECs. PAECs were transiently… CONTINUE READING

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Mitochondria in the etiology and L209 MTDNA DAMAGE AND LUNG ENDOTHELIAL CELL DEATH AJP-Lung Cell Mol Physiol

  • AH Schapira, M Gu, +4 authors JM. Cooper
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