Enhanced molecular mimicry of CEA using photoaffinity crosslinked C3d peptide


Antigen mimicry of using anti-idiotypic antibodies for use as cancer vaccines has been disappointing due to the weak immunogenicity of immunoglobulin variable domains. To enhance the immunogenicity of an anti-idiotype vaccine we incorporated a molecular adjuvant peptide into the antibody. The peptide is derived from the C3d region known to bind CR2… (More)
DOI: 10.1038/nbt0598-458