Enhanced metabolism of Leishmania donovani amastigotes at acid pH: an adaptation for intracellular growth.

@article{Mukkada1985EnhancedMO,
  title={Enhanced metabolism of Leishmania donovani amastigotes at acid pH: an adaptation for intracellular growth.},
  author={Antony J Mukkada and J C Meade and Theodor Glaser and Peter F. Bonventre},
  journal={Science},
  year={1985},
  volume={229 4718},
  pages={1099-101}
}
Amastigotes (tissue forms) of Leishmania donovani isolated from infected hamster spleens carried out several physiological activities (respiration, catabolism of energy substrates, and incorporation of precursors into macromolecules) optimally at pH 4.0 to 5.5. All metabolic activities that were examined decreased sharply above the optimal pH. Promastigotes (culture forms), on the other hand, carried out the same metabolic activities optimally at or near neutral pH. This adaptation to an acid… CONTINUE READING