Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat.

Abstract

Here we assessed the effects of i.g. administration of Zingicomb (ZC), a mixture of zingiber officinale and ginkgo biloba extracts, on learning and memory, and on indicators of oxidative stress in aged rats. Effects of ZC (1 and 10 mg/kg) were investigated in 22-24 months old Wistar rats using the Morris water maze, in which they show deficient performance as compared to 3 months old rats in the undrugged state (days 1 and 2). Treatment was administered on days 3 and 4 of training, then over 7 days with training discontinued, and again on days 5 and 6 when training was resumed. Thereafter chronic treatment was maintained over 5 months. 1 mg/kg ZC improved escape learning in the water maze. The two capital indicators of oxidative stress in brain homogenates, the amount of oxidized proteins (assessed as carbonyl group containing proteins) and lipid peroxidation, were significantly reduced in ZC treated animals. Thus, ZC, which had previously been shown to improve inhibitory avoidance learning and to have anxiolytic properties in adult animals, might also facilitate spatial learning in aged animals, and reduces indices of oxidative stress in brain tissue after chronic treatment.

Statistics

01002003002008200920102011201220132014201520162017
Citations per Year

366 Citations

Semantic Scholar estimates that this publication has 366 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Topic2002EnhancedMP, title={Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat.}, author={Bianca Topic and Ekaterini Tani and Kariofyllis Tsiakitzis and Panos N. Kourounakis and E. Dere and R{\"{u}diger U Hasen{\"{o}hrl and Ryan Haecker and Claudia Mattern and Joseph P. Huston}, journal={Neurobiology of aging}, year={2002}, volume={23 1}, pages={135-43} }