Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from Fragile X mental retardation 1-deficient mice, a pathological model for Fragile X syndrome.

@article{Bekay2007EnhancedMO,
  title={Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from Fragile X mental retardation 1-deficient mice, a pathological model for Fragile X syndrome.},
  author={Rajaa El Bekay and Yanina Romero-Zerbo and Juan Manuel Decara and Lourdes S{\'a}nchez-Salido and Ignacio del Arco-Herrera and Fernando Rodr{\'i}guez-de Fonseca and Yolanda de Diego-Otero},
  journal={The European journal of neuroscience},
  year={2007},
  volume={26 11},
  pages={3169-80}
}
Fragile X syndrome is the most common form of inherited mental retardation in humans. It originates from the loss of expression of the Fragile X mental retardation 1 (FMR1) gene, which results in the absence of the Fragile X mental retardation protein. However, the biochemical mechanisms involved in the pathological phenotype are mostly unknown. The availability of the FMR1-knockout mouse model offers an excellent model system in which to study the biochemical alterations related to brain… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…