Enhanced maintenance and functions of rat hepatocytes induced by combination of on-site oxygenation and coculture with fibroblasts.

@article{Nishikawa2008EnhancedMA,
  title={Enhanced maintenance and functions of rat hepatocytes induced by combination of on-site oxygenation and coculture with fibroblasts.},
  author={Masaki Nishikawa and Nobuhiko Kojima and Kikuo Komori and Takatoki Yamamoto and Teruo Fujii and Yasuyuki Sakai},
  journal={Journal of biotechnology},
  year={2008},
  volume={133 2},
  pages={253-60}
}
In in vivo liver tissue, each hepatocyte has intimate interactions not only with adjacent hepatocytes but also with nonparenchymal cells in a three-dimensional (3D) manner. We recently reported that hepatic function is highly maintained on collagen covalently immobilized poly-dimethylsiloxane (PDMS) membranes through which oxygen is supplied directly to the… CONTINUE READING