Enhanced macrophage uptake of synthetically glycosylated human placental beta-glucocerebrosidase.
@article{Doebber1982EnhancedMU, title={Enhanced macrophage uptake of synthetically glycosylated human placental beta-glucocerebrosidase.}, author={Thomas W. Doebber and M. S. Wu and Robert L. Bugianesi and Mitree M. Ponpipom and F S Furbish and John A. Barranger and Roscoe O. Brady and Tsung Ying Shen}, journal={The Journal of biological chemistry}, year={1982}, volume={257 5}, pages={ 2193-9 } }
72 Citations
Targeting of synthetically glycosylated human placental glucocerebrosidase.
- Biology, ChemistryBiochemical medicine
- 1985
Lectin-specific targeting of lysosomal enzymes to reticuloendothelial cells.
- BiologyMethods in enzymology
- 1987
Glucocerebrosidase deficiency and lysosomal storage of glucocerebroside induced in cultured macrophages.
- Biology, ChemistryExperimental cell research
- 1987
Uptake of Mannose-Terminal Glucocerebrosidase in Cultured Human Cholinergic and Dopaminergic Neuron Cell Lines
- Biology, MedicineNeurochemical Research
- 2004
Mannose-terminal glucocerebrosidase was taken up by cholinergic LA-N-2 cells, but to a much lower extent than by macrophages, and considerably less of the enzyme was endocytosed by dopaminergic SH-SY5Y cells, and it was not taking up by NHA astrocytes.
Replacement therapy for inherited enzyme deficiency--macrophage-targeted glucocerebrosidase for Gaucher's disease.
- Medicine, BiologyThe New England journal of medicine
- 1991
Intravenous administration of macrophage-targeted glucocerebrosidase produces objective clinical improvement in patients with type 1 Gaucher's disease.
Failure of Alglucerase Infused into Gaucher Disease Patients to Localize in Marrow Macrophages
- Medicine, BiologyMolecular medicine
- 1995
Even with the large bolus doses used for the treatment of Gaucher disease by some, scarcely any β-glucosidase activity was found in marrow samples; the amount of the enzyme was much less than would have been anticipated had the enzyme been evenly distributed to all body cells.
Saccharide Receptor-Mediated Drug Delivery
- Biology, Chemistry
- 1984
Carohydrate-mediated endocytosis in mammals has since become the subject of intensive studies and macrophages and Kupffer cells have been shown to bind glycoproteins and synthetic neoglycoconjugates that have D-mannose and 2-acetamido-2-deoxy-D-glucose in the exposed non-reducing position.
Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes
- BiologyPloS one
- 2017
This study suggests that further insight in targeting and efficacy of enzyme therapy of individual Gaucher patients could be obtained by the use of recombinant GBA, trace-labeled with an ABP, preferably equipped with an infrared fluorophore or other reporter tag suitable for in vivo imaging.
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
- BiologyPlant biotechnology journal
- 2007
The production of a recombinant human GCD in a carrot cell suspension culture shows a level of biological activity similar to that of Cerezyme produced in CHO cells, as well as a highly homologous high-resolution three-dimensional structure, determined by X-ray crystallography, indicating the potential safety of prGCD.
Receptor mediated binding of two glycosylation forms of N-acetylgalactosamine-4-sulphatase.
- Biology, ChemistryBiochimica et biophysica acta
- 1998