Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching.

@article{Papadopoulos2004EnhancedMD,
  title={Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching.},
  author={Marios C Papadopoulos and Devin K. Binder and Alan S Verkman},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={19 3},
  pages={
          425-7
        }
}
Diffusion of solutes and macromolecules in brain extracellular space (ECS) is important for normal brain function and efficient drug delivery, and is thought to be impaired in edematous brain. Here we measured the diffusion of an inert macromolecular fluorescent marker (FITC-dextran, 70 kDa) in the ECS by fluorescence recovery after photobleaching after staining the exposed cerebral cortex in vivo. In a brain tumor model of vasogenic (leaky capillary) edema, FITC-dextran diffusion was reduced… CONTINUE READING

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