Enhanced levels of endogenous endothelin-1 contribute to the over expression of Giα protein in vascular smooth muscle cells from SHR: Role of growth factor receptor activation.

@article{Sandoval2011EnhancedLO,
  title={Enhanced levels of endogenous endothelin-1 contribute to the over expression of Giα protein in vascular smooth muscle cells from SHR: Role of growth factor receptor activation.},
  author={Yessica-Haydee Gomez Sandoval and Madhu B Anand-Srivastava},
  journal={Cellular signalling},
  year={2011},
  volume={23 2},
  pages={354-62}
}
We earlier showed that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit increased expression of Gi proteins. Since the levels of endothelin-1 (ET-1) are enhanced in VSMC from SHR, we undertook the present study to examine the implication of endogenous ET-1 and the underlying mechanisms in the enhanced expression of Gi… CONTINUE READING