Enhanced kidney allocation to highly sensitized patients by the acceptable mismatch program.

@article{Claas2009EnhancedKA,
  title={Enhanced kidney allocation to highly sensitized patients by the acceptable mismatch program.},
  author={Franz H J Claas and Axel Rahmel and Iiias I N Doxiadis},
  journal={Transplantation},
  year={2009},
  volume={88 4},
  pages={
          447-52
        }
}
Even in this era of efficient immunosuppression, a positive serological crossmatch caused by complement fixing antibodies directed against the human leukocyte antigen (HLA) mismatches of the organ donor is a contraindication for transplantation (1). The presence of this type of antibodies is known to be associated with a high incidence of hyper acute or acute-accelerated rejection (2). Highly sensitized patients have only a small chance to receive a crossmatch negative donor kidney, because… CONTINUE READING

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