Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor.

@article{King1997EnhancedKR,
  title={Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor.},
  author={Michael King and Ying-Xian Pan and Jingjing Mei and Alexander Chang and Jin Xu and Gavril W Pasternak},
  journal={European journal of pharmacology},
  year={1997},
  volume={331 1},
  pages={R5-6}
}
In the current study, we used an antisense oligodeoxynucleotide targeting the recently cloned sigma1 receptor to assess its functions within the nervous system. Sigma1 antagonists potentiate the analgesic actions of opioids. Similarly, the antisense probe targeting the sigma1 receptor enhanced the analgesic activity of the kappa1-opioid receptor agonist U50… CONTINUE READING