Enhanced invasive properties exhibited by smooth muscle cells are associated with elevated production of MMP-2 in patients with aortic aneurysms.

@article{Goodall2002EnhancedIP,
  title={Enhanced invasive properties exhibited by smooth muscle cells are associated with elevated production of MMP-2 in patients with aortic aneurysms.},
  author={Stephen Goodall and Karen E Porter and Peter R. F. Bell and Matthew M. Thompson},
  journal={European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery},
  year={2002},
  volume={24 1},
  pages={72-80}
}
BACKGROUND abdominal aortic aneurysms (AAA) are associated with excessive vascular matrix remodelling. Recent findings suggest a systemic overproduction of matrix metalloproteinases-2 (MMP-2) by vascular smooth muscle cells (SMC) may be pivotal aetiologically. SMC migration is facilitated by MMP mediated proteolysis of the basement membrane and extracellular matrix. Our aim was to see if enhanced MMP-2 production by these SMC exhibit increased invasion, in an in vitro model of migration… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Age-related Impairment of Vascular Structure and Functions

Aging and disease • 2017
View 5 Excerpts
Highly Influenced

Association of Matrix Metalloproteinase Levels with Collagen Degradation in the Context of Abdominal Aortic Aneurysm.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery • 2017

Similar Papers

Loading similar papers…