Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice.

@article{Naito2003EnhancedII,
  title={Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice.},
  author={Yuji Naito and Tomohisa Takagi and Osamu Handa and Takeshi Ishikawa and Shuji Nakagawa and Taiji Yamaguchi and Norimasa Yoshida and Masato Minami and Masakazu Kita and Jiro Imanishi and Toshikazu Yoshikawa},
  journal={Journal of gastroenterology and hepatology},
  year={2003},
  volume={18 5},
  pages={560-9}
}
BACKGROUND AND AIMS Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory cytokine thought to be involved in the pathogenesis of inflammatory bowel disease. To further define the role of TNF-alpha in intestinal inflammation, we studied the effects of dextran sulfate sodium (DSS) administration in mice with targeted deletions of TNF-alpha gene. METHODS Acute colitis was induced in female TNF-alpha-/- and TNF-alpha+/+ mice by administering 4.5% DSS orally in drinking water for… CONTINUE READING

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