Enhanced interferon-gamma-induced Ia-antigen expression by glial cells after previous exposure to this cytokine.

  • D. Sun
  • Published 1991 in Journal of neuroimmunology

Abstract

Encephalitogenic T cells appear capable of destroying class II major histocompatibility complex (MHC) antigen (Ia)-positive glial cells in the brain, thus accounting for the pathologic activity of these lymphocytes in experimental autoimmune encephalomyelitis (EAE). However, glial cells do not generally express Ia molecules, suggesting that regulation of Ia… (More)

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