Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery.

@article{Albers2015EnhancedIS,
  title={Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery.},
  author={Peter H. Albers and Kirstine N Bojsen-M\oller and Carsten Dirksen and Annette Karen Serup and Dorte E Kristensen and Jan Frystyk and Trine Ryberg Clausen and Bente Kiens and Erik A Richter and Sten Madsbad and J\orgen F P Wojtaszewski},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2015},
  volume={309 5},
  pages={R510-24}
}
Roux-en-Y gastric bypass (RYGB) leads to increased peripheral insulin sensitivity. The aim of this study was to investigate the effect of RYGB on expression and regulation of proteins involved in regulation of peripheral glucose metabolism. Skeletal muscle and adipose tissue biopsies from glucose-tolerant and type 2 diabetic subjects at fasting and during a hyperinsulinemic-euglycemic clamp before as well as 1 wk and 3 and 12 mo after RYGB were analyzed for relevant insulin effector proteins… CONTINUE READING