Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep.

@article{Chen2014EnhancedIS,
  title={Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep.},
  author={Xiaochuan Chen and Alice S Green and Antoni Ryszard Macko and Dustin T. Yates and Amy C Kelly and Sean W Limesand},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={306 1},
  pages={
          E58-64
        }
}
Intrauterine growth-restricted (IUGR) fetuses experience prolonged hypoxemia, hypoglycemia, and elevated norepinephrine (NE) concentrations, resulting in hypoinsulinemia and β-cell dysfunction. Previously, we showed that acute adrenergic blockade revealed enhanced insulin secretion responsiveness in the IUGR fetus. To determine whether chronic exposure to NE alone enhances β-cell responsiveness afterward, we continuously infused NE into fetal sheep for 7 days and, after terminating the infusion… CONTINUE READING

Citations

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Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2017
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