Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas.

@article{Smith1991EnhancedIG,
  title={Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas.},
  author={Fannie E. Smith and K. M. Rosen and L. Villa-Komaroff and Gordon C Weir and Susan Bonner-Weir},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 14},
  pages={6152-6}
}
Insulin-like growth factor I (IGF-I) mRNA expression was studied after 90% partial pancreatectomy in the rat to determine whether IGF-I was associated with pancreatic regeneration. The level of IGF-I mRNA was maximally increased (4-fold above control value) 3 days after pancreatectomy, but thereafter gradually decreased, returning to control levels by 14 days after surgery. By in situ hybridization, IGF-I mRNA in both pancreatectomized and sham-operated rats was localized to capillary… CONTINUE READING

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