Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite.

  title={Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite.},
  author={Koji Morita and Kazuya Doi and Toshikazu Kubo and Ryou Takeshita and Shinichi Kato and Toshikazu Shiba and Yasumasa Akagawa},
  journal={Acta biomaterialia},
  volume={6 7},
Inorganic polyphosphate (poly(P)) can promote binding between fibroblast growth factors and their receptors and enhance osteoblastic cell differentiation and calcification. This study evaluated the possibilities for poly(P) adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) as a new bone regeneration material. Prepared 1%, 5%, 25% and 50% poly(P)/IP-CHA composites showed the elution peak of poly(P) between 15 and 20 min, respectively, with the highest value from 50% poly(P)/IP… CONTINUE READING
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