Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.

@article{Ogawa1997EnhancedIO,
  title={Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.},
  author={Michio Ogawa and Takeki Tsutsui and J P Zou and Jie Mu and R Wijesuriya and Weiyun Yu and Steven H Herrmann and Takeshi Kubo and Hiromi Fujiwara and Toshiyuki Hamaoka},
  journal={Cancer research},
  year={1997},
  volume={57 11},
  pages={2216-22}
}
Administration of interleukin 12 (IL-12) into mice bearing CSA1M, OV-HM, Meth A, or MCH-1-A1 tumor induced complete regression of CSA1M and OV-HM tumors but induced only a slight growth inhibition of Meth A and MCH-1-A1 tumors. These effects of IL-12 were associated with high and only marginal levels of T-cell infiltration into CSA1M/OV-HM and Meth A/MCH-1-A1 tumor masses, respectively. Here, we investigated the role of IL-12 in the induction of T-cell migration. Spleen cells from untreated or… CONTINUE READING