Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice.

@article{Saleiro2010EnhancedIO,
  title={Enhanced induction of mucin-depleted foci in estrogen receptor \{beta\} knockout mice.},
  author={Diana Saleiro and Genoveva Murillo and Dennis B. Lubahn and Levy Kopelovich and Kenneth S. Korach and Rajendra G. Mehta},
  journal={Cancer prevention research},
  year={2010},
  volume={3 9},
  pages={1198-204}
}
The role of the estrogen receptor beta (ERbeta) in the colon has received considerable interest, yet in vivo models are needed to better define its protective actions. In the present study, wild-type (WT), ERalpha, and ERbeta knockout (alphaERKO and betaERKO) mice were injected with azoxymethane, a colon chemical carcinogen. Fourteen weeks after azoxymethane exposure, the incidence of aberrant crypt foci (ACF) was assessed by methylene blue staining. betaERKO mice showed significantly higher… CONTINUE READING