Enhanced induction of human WT1-specific cytotoxic T lymphocytes with a 9-mer WT1 peptide modified at HLA-A*2402-binding residues

@article{Tsuboi2002EnhancedIO,
  title={Enhanced induction of human WT1-specific cytotoxic T lymphocytes with a 9-mer WT1 peptide modified at HLA-A*2402-binding residues},
  author={Akihiro Tsuboi and Y. Oka and Keiko Udaka and Masaki Murakami and Tomoki Masuda and Akiko Nakano and Hiroko Nakajima and Masaki Yasukawa and A. U. Hiraki and Yusuke Oji and Manabu Kawakami and Naoki Hosen and Tatsuya Fujioka and Fei Wu and Yuki Taniguchi and Sumiyuki Nishida and Momotaro Asada and Hiroyasu Ogawa and Yoshihisa Kawase and Haruo Sugiyama},
  journal={Cancer Immunology, Immunotherapy},
  year={2002},
  volume={51},
  pages={614-620}
}
The Wilms' tumor gene WT1 is overexpressed in most types of leukemias and various kinds of solid tumors, including lung and breast cancer, and participates in leukemogenesis and tumorigenesis. WT1 protein has been reported to be a promising tumor antigen in mouse and human. In the present study, a single amino-acid substitution, M→Y, was introduced into the first anchor motif at position 2 of the natural immunogenic HLA-A*2402-restricted 9-mer WT1 peptide (CMTWNQMNL; a.a. 235–243). This… CONTINUE READING
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