Enhanced in vivo growth of lymphoma tumors in the absence of the NK-activating receptor NKp46/NCR1.

@article{Halfteck2009EnhancedIV,
  title={Enhanced in vivo growth of lymphoma tumors in the absence of the NK-activating receptor NKp46/NCR1.},
  author={Gili G. Halfteck and Moran Elboim and Chamutal Gur and Hagit Achdout and Hormas Ghadially and Ofer Mandelboim},
  journal={Journal of immunology},
  year={2009},
  volume={182 4},
  pages={2221-30}
}
The in vitro elimination of virus-infected and tumor cells by NK cells is regulated by a balance between signals conveyed via specific inhibitory and activating receptors. Whether NK cells and specifically the NK-activating receptor NKp46 (NCR1 in mice) are directly involved in tumor eradication in vivo is still largely unknown. Since the NKp46/NCR1 tumor ligands have not been identified yet, we use a screening technique to identify functional ligands for NKp46/NCR1 which is based on a cell… CONTINUE READING
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