Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation.

  title={Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation.},
  author={Makiya Nishikawa and Mitsuhiro Matono and Sakulrat Rattanakiat and Nao Matsuoka and Yoshinobu Takakura},
  volume={124 2},
DNA containing unmethylated CpG dinucleotides (CpG DNA) is a potent activator of innate and acquired immune responses. Although the sequence-specific immunostimulatory activity of CpG DNA has been extensively explored, little information is available about the importance of the stereochemical properties of CpG DNA. In this study, Y-shaped oligodeoxynucleotides (Y-ODNs) were prepared using three ODNs with the halves of each ODN being partially complementary to a half of the other two ODNs. Y-ODN… CONTINUE READING

From This Paper

Topics from this paper.
26 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…