Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers.

@article{Glaffig2015EnhancedIO,
  title={Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers.},
  author={Markus Glaffig and Bj{\"o}rn Palitzsch and Natascha Stergiou and Christoph Sch{\"u}ll and David Stra\ssburger and Edgar Schmitt and Hellmuth Frey and Horst Kunz},
  journal={Organic & biomolecular chemistry},
  year={2015},
  volume={13 40},
  pages={10150-4}
}
Enhancing the immunogenicity of an antitumour vaccine still poses a major challenge. It depends upon the selected antigen and the mode of its presentation. We here describe a fully synthetic antitumour vaccine, which addresses both aspects. For the antigen, a tumour-associated MUC1 glycopeptide as B-cell epitope was synthesised and linked to the immunostimulating T-cell epitope P2 derived from tetanus toxoid. The MUC1-P2 conjugate is presented multivalently on a hyperbranched polyglycerol to… CONTINUE READING
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