Enhanced immunogenicity of microencapsulated multiepitope DNA vaccine encoding T and B cell epitopes of foot-and-mouth disease virus in mice.

@article{Wang2006EnhancedIO,
  title={Enhanced immunogenicity of microencapsulated multiepitope DNA vaccine encoding T and B cell epitopes of foot-and-mouth disease virus in mice.},
  author={Fang Wang and Xiao-Wen He and Lei Jiang and Ding Ren and Ying He and D Li and Shu-Han Sun},
  journal={Vaccine},
  year={2006},
  volume={24 12},
  pages={2017-26}
}
The role of poly(D,L-lactic-co-glycolic acid, PLGA) microparticles on enhancing immune responses of multiepitope DNA vaccines was investigated in vitro and in vivo. pcDNA-SG encoding T and B cell epitopes of foot-and-mouth disease virus (FMDV) was encapsulated into PLGA microparticles. PLGA microparticles could protect themselves from nuclease degradation… CONTINUE READING