Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein.

@article{Cooney1993EnhancedIT,
  title={Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein.},
  author={E L Cooney and M Juliana McElrath and Lawrence Corey and Shiu Lok Hu and Ann C Collier and D E Arditti and Mary C Hoffman and Robert W. Coombs and Gary E. Smith and Philip D. Greenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 5},
  pages={1882-6}
}
Transmission studies have suggested that an optimal human immunodeficiency virus type 1 (HIV-1) vaccine should induce both neutralizing antibodies and cytolytic T cells to eliminate free virus and infected cells. A phase I trial in healthy HIV-1-seronegative persons was conducted with a combination HIV-1 vaccine regimen (strain IIIB) consisting of priming with a recombinant vaccinia (vac/env) virus expressing HIV-1 envelope and boosting with a gp160 glycoprotein derived from a recombinant… CONTINUE READING

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