Enhanced immunity and protective efficacy against SIVmac251 intrarectal challenge following ad-SIV priming by multiple mucosal routes and gp120 boosting in MPL-SE.

@article{Pinczewski2005EnhancedIA,
  title={Enhanced immunity and protective efficacy against SIVmac251 intrarectal challenge following ad-SIV priming by multiple mucosal routes and gp120 boosting in MPL-SE.},
  author={Joel Pinczewski and Jian Zhao and Nina V Malkevitch and Linda J Patterson and Kristine Aldrich and W. Gregory Alvord and Marjorie Robert-Guroff},
  journal={Viral immunology},
  year={2005},
  volume={18 1},
  pages={
          236-43
        }
}
Previously, 39% of rhesus macaques primed orally, intranasally, and intratracheally with adenovirus (Ad)-simian immunodeficiency virus (SIV) recombinants and boosted with gp120 in monophosphoryl lipid A-stable emulsion (MPL-SE) remained aviremic or cleared or controlled viremia at the threshold of detection following SIV(mac251) intrarectal challenge (Study B). In contrast, no macaques primed orally and intranasally with Ad-SIV recombinants and boosted with gp120 in Quillaja Saponaria-21… CONTINUE READING
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