Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.

@article{Wichmann1996EnhancedIR,
  title={Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.},
  author={Matthias W. Wichmann and Rene Zellweger and C. M. DeMaso and Alfred Ayala and Irshad H. Chaudry},
  journal={Cytokine},
  year={1996},
  volume={8 11},
  pages={853-63}
}
Although haemorrhagic shock produces immunodepression in both humans and experimental animals, no information is available concerning gender differences in the immune and endocrine response to shock. To study this, male and female (proestrus and diestrus) C3H/HeN mice (25 g body weight) were bled and maintained at a mean arterial blood pressure of 35 +/- 5 mmHg for 1 h and then adequately resuscitated. The animals were killed at 2 h after resuscitation to obtain splenocytes, macrophages (M phi… CONTINUE READING

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