Enhanced immune responses and effectiveness of refined outer membrane protein vaccines against Vibrio harveyi in orange-spotted grouper (Epinephelus coioides).

@article{Nguyen2018EnhancedIR,
  title={Enhanced immune responses and effectiveness of refined outer membrane protein vaccines against Vibrio harveyi in orange-spotted grouper (Epinephelus coioides).},
  author={Hai Trong Nguyen and Thuy T. Nguyen and Yan-chun Chen and Hung Vu-Khac and Pei-Chi Wang and Shih‐Chu Chen},
  journal={Journal of fish diseases},
  year={2018},
  volume={41 9},
  pages={
          1349-1358
        }
}
Vibriosis is a severe infection occurring in many commercially important marine fish species. In this study, vaccines containing Vibrio harveyi recombinant outer membrane protein K (rOmpK), outer membrane protein U (rOmpU) and rOmpK-OmpU fusion protein in addition to the metabolizable MontanideTM ISA 763 A VG adjuvant were developed and evaluated in the orange-spotted grouper. The results indicate that recombinant V. harveyi protein-based vaccines resulted in a remarkably higher expression of… Expand
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