Enhanced immune recognition of cryptic glycan markers in human tumors.

  title={Enhanced immune recognition of cryptic glycan markers in human tumors.},
  author={Thomas E Newsom-Davis and Denong Wang and Lawrence Steinman and Paul F-T Chen and L Wang and Anna Katharina Simon and Gavin Robert Screaton},
  journal={Cancer research},
  volume={69 5},
Abnormal glycosylation is one of the hallmarks of the cancer cell and is associated with tumor invasion and metastasis. The development of tumor-associated carbohydrate antigen (TACA) vaccines has been problematic due to poor immunogenicity. However, when appropriate targets can be identified, passive immunization with monoclonal antibodies (mAbs) directed against TACAs has been shown to have antitumor activity. Fas ligand (FasL) is a transmembrane protein that induces apoptosis in cells… CONTINUE READING


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