Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide.

Abstract

Major histocompatibility complex class I molecules can be expressed as single polypeptides wherein the antigenic peptide, beta2-microglobulin, and heavy chain are attached by flexible linkers. These molecules, single-chain trimers (SCTs), are remarkably stable at the cell surface compared with native (noncovalently attached) class I molecules. In this study… (More)

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Cite this paper

@article{Lybarger2003EnhancedIP, title={Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide.}, author={Lonnie P Lybarger and Yik Yeung Lawrence Yu and Michael J. Miley and Daved H. Fremont and Nancy B. Myers and Tina M Primeau and Steven M. Truscott and Janet M. Connolly and Ted H. Hansen}, journal={The Journal of biological chemistry}, year={2003}, volume={278 29}, pages={27105-11} }