Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain.

@article{Goldman1998EnhancedHC,
  title={Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain.},
  author={Jacki P. Goldman and Michael Patrick Blundell and Luciene Lopes and Christine Kinnon and James P Di Santo and Adrian J. Thrasher},
  journal={British journal of haematology},
  year={1998},
  volume={103 2},
  pages={335-42}
}
Xenotransplantation of human cells into immunodeficient mice has been used to develop models of human haemopoiesis and lymphoid cell function. However, the utility of existing mouse strains can be limited by shortened life-spans, spontaneous production of functional lymphocytes with ageing, and residual innate immunity leading to variable levels of engraftment. Mice with a deletion of the common cytokine receptor gamma chain (gamma c) gene have reduced numbers of peripheral T and B lymphocytes… CONTINUE READING
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