Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2).

@article{Witthoeft2005EnhancedHB,
  title={Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2).},
  author={Th Witthoeft and Claudia S. Pilz and Klaus Fellermann and Maximilian J E Nitschk{\'e} and Eduard F Stange and Diether Ludwig},
  journal={Digestive diseases and sciences},
  year={2005},
  volume={50 7},
  pages={1252-9}
}
Beta-defensins are small cationic peptides with antimicrobial properties that contribute to innate host defense. Unlike human beta-defensin-1 (hBD-1), which is produced constitutively, human beta-defensin-2 (hBD-2) is expressed after adequate stimulation by cytokines and/or bacterial endotoxins in epithelial tissue and mononuclear phagocytes but may be deficient in patients with Crohn's disease. To further elucidate the role of the intestinal epithelium in antimicrobial host defense, gene… CONTINUE READING