Enhanced hippocampal neurogenesis by intraventricular S100B infusion is associated with improved cognitive recovery after traumatic brain injury.

@article{Kleindienst2005EnhancedHN,
  title={Enhanced hippocampal neurogenesis by intraventricular S100B infusion is associated with improved cognitive recovery after traumatic brain injury.},
  author={Andrea Kleindienst and Melissa J. McGinn and Harlan B Harvey and Raymond J. Colello and Robert J Hamm and Malcolm Ross Bullock},
  journal={Journal of neurotrauma},
  year={2005},
  volume={22 6},
  pages={645-55}
}
Evidence of injury-induced neurogenesis in the adult hippocampus suggests that an endogenous repair mechanism exists for cognitive dysfunction following traumatic brain injury (TBI). One factor that may be associated with this restoration is S100B, a neurotrophic/mitogenic protein produced by astrocytes, which has been shown to improve memory function. Therefore, we examined whether an intraventricular S100B infusion enhances neurogenesis within the hippocampus following experimental TBI and… CONTINUE READING

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Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury

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  • J. Neurotrauma
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