Enhanced helminthotoxic capacity of eosinophils from patients with eosinophilia.

@article{David1980EnhancedHC,
  title={Enhanced helminthotoxic capacity of eosinophils from patients with eosinophilia.},
  author={J. Rushton David and Mathew A. Vadas and Anthony E. Butterworth and P A de Brito and Edgar Marcelino de Carvalho and R. A. David and Jos{\'e} Carlos Bina and Zilton de Ara{\'u}jo Andrade},
  journal={The New England journal of medicine},
  year={1980},
  volume={303 20},
  pages={
          1147-52
        }
}
To determine whether eosinophils from patients with eosinophilia have an enhanced capacity to kill parasites, we compared purified eosinophils (mean purity, 89 per cent) from 30 patients with various degrees of eosinophilia and with or without infection with Schistosoma mansoni for the capacity to kill schistosomula, the larval stage of S. mansoni, in vitro. There was a significant correlation between peripheral eosinophil count and antibody-dependent, eosinophil-mediated death of parasites… CONTINUE READING
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