Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C.

@article{Silva2009EnhancedGO,
  title={Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C.},
  author={Odete A. B. da Cruz e Silva and Sandra Rebelo and Sandra Isabel Vieira and Sam Gandy and Edgar F. da Cruz e Silva and Paul Greengard},
  journal={Journal of neurochemistry},
  year={2009},
  volume={108 2},
  pages={319-30}
}
Alzheimer's amyloid precursor protein (APP) sorting and processing are modulated through signal transduction mechanisms regulated by protein phosphorylation. Notably, protein kinase C (PKC) appears to be an important component in signaling pathways that control APP metabolism. PKCs exist in at least 11 conventional and unconventional isoforms, and PKCalpha and PKCepsilon isoforms have been specifically implicated in controlling the generation of soluble APP and amyloid-beta (Abeta) fragments of… CONTINUE READING

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